2021 ISAKOS Biennial Congress ePoster
Development Of An Experimental Model Of Glenohumeral Osteoarthritis: Effect Of Arthroscopic Tenotomy Of The Long Head Of The Biceps Tendon And Section Of The Anterior Joint Capsule
Vincenzo Candela, Roma, Rm ITALY
Umile Giuseppe Longo, MD, MSc, PhD, Prof., Rome ITALY
Salvatore Maria Maria Tecce, MD, Roma, --- ITALY
Francisco Forriol, MD, PhD, Madrid SPAIN
Jose R Altonaga, MD, León SPAIN
Andrew L Wallace, MD, London UNITED KINGDOM
Vincenzo Denaro, MD, PhD, Prof., Rome ITALY
Universidad de León, León, EUROPE, SPAIN
FDA Status Not Applicable
Summary
An animal model for analyzing the effects of arthroscopic tenotomy of the long head of the biceps tendon and section of the anterior gleno-humeral joint capsule on the ovine gleno-humeral joint has been developed. The arthroscopic tenotomy of the long head of the biceps tendon and section of the anterior gleno-humeral joint capsule caused moderate degenerative changes to the ovine shoulder joint.
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Abstract
Background
Osteoarthritis (OA) of the glenohumeral (GH) joint is a common cause of shoulder pain, resulting in considerable invalidity. However, the study of OA pathogenesis is not easy. OA models are needed to identify targets for treatment and to interfere with OA development and progression. Human joint tissues are scarcely available and can be only obtained in sufficient quantities during joint replacement. To overcome this hurdle and to identify targets for treatment and ways to interfere with OA development and progression, animal OA models are needed. Despite several models of surgically induced destabilization of knee joint are available, few studies evaluated the degenerative changes in the articular cartilages of the shoulder in surgical models of joint destabilization.
AIMS
To evaluate the effect of an arthroscopic tenotomy of the long head of the biceps tendon and section of the anterior gleno-humeral joint capsule on the ovine gleno-humeral joint.
Methods
Eight sheep were used for the study. According to indications of OARSI , only “skeletally mature” (>/= 2 years of age) animals were selected. Sheep were kept in individual cages and were fed with a standard diet and water ad libitum. All animals were healthy and free of any other disease. Sheep were housed in a temperature-controlled room (23 °C) with a normal 12-h light/dark cycle (6:00 am–6:00 pm). Sheep received an arthroscopic tenotomy of the long head of the biceps tendon and section of the anterior joint capsule. Sheep were euthanized by lethal injection of phenobarbitone at 4 months after surgery. Macroscopic assessments, microscopic findings and MRI throughout the gleno-humeral joints of all animals were performed.
Results
All animals tolerated the surgery well and survived for 6 weeks with no complications. Moderate degenerative changes to the ovine shoulder joint were found on MRI and histological evaluation..
Discussion
The arthroscopic tenotomy of the long head of the biceps tendon and section of the anterior gleno-humeral joint capsule caused moderate degenerative changes to the ovine shoulder joint. Animal models provide a useful tool to track the progression of osteoarthritis from its earliest stages and exhibit changes similar to the human condition. The arthroscopic tenotomy of the long head of the biceps tendon and section of the anterior gleno-humeral joint capsule was never used before to the best of our knowledge.