Page 41 - ISAKOS 2019 Newsletter Vol II

COMMITTEE UPDATE
Therefore, the purpose of this study was to compare hyaline cartilage regeneration following the implantation of a tissue engineering construct (TEC) loaded with dental pulp stem cells (DPSCs) and synovial / fat pad stem cells (FPSCs) in a large-animal (pig) model. The investigators started the experiments in March 2018, and, currently, 70% of their subjects have been enrolled, with recruitment and assessments ongoing. The animal model experiments were completed May 2019. There have been three publications4 – 6 and five presentations at national and international conferences related to this grant. The promising results are upcoming and will enhance our understanding of cartilage repair.
Clinical Outcomes Grant
The Clinical Outcomes research grant was awarded to principal investigator Dr. Robert G. Marx (Hospital for Special Surgery, New York , NY) and colleagues for “Cluster RCT of Implementation Strategies for ACL Injury Prevention.” Despite the development of ACL injury-prevention programs over the last decades, ACL injury rates have not decreased. The reasons for this finding may include a limited understanding of, and poor compliance with, the proper implementation of prevention programs. Therefore, these investigators performed a cluster-randomized controlled trial that compared compliance with ACL injury- prevention programs between the school team coaches who participated in an ACL injury-prevention training workshop and those who did not. Throughout the course of this trial, 40 high school sports coaches and 21 sports teams were enrolled. Blinded data collectors were hired to observe and document compliance with the prevention exercises prior to practices and games throughout the winter and spring sports seasons. This grant will inform practice about the best way to educate coaches about ACL injury-prevention programs to improve compliance.
Countries with Limited Resources Grant
Last, ISAKOS has developed a unique grant, the ISAKOS Young Investigator’s Scholarship and Research Mentoring Program, for young researchers from countries with limited access to research resources. This program seeks to assist young surgeons to advance their research by awarding a fellowship at an ISAKOS-recognized research facility and funding an ISAKOS-approved mentorship. This program consists of two parts. In Part I, twenty scholarship recipients receive a $1,500 stipend to support their travel and participation to the Biennial ISAKOS Congress. At the 2019 Congress in Cancun, Mexico, all of the awardees were invited to attend a research symposium at which they received the ISAKOS book entitled Basic Methods Handbook for Clinical Orthopaedic Research (Fig. 2). In Part II, four finalists are interviewed by the ISAKOS Scientific Committee at the Congress, and two are awarded a scholarship to complete a research project along with the guidance of a research mentor (determined by the researcher and ISAKOS Scientific Committee).
At the 2017 meeting, Drs. Juan Pablo Martinez (from Columbia) and Saroj Rai (from NEPAL) were awarded this grant. Dr. Martinez participated in a mentorship with Dr. Constance Chu at Stanford University, with a focus on regenerative medicine, and Dr. Rai participated in a mentorship with Drs. Volker Musahl and Freddie H. Fu at the University of Pittsburgh, with a focus on clinical outcomes research. Dr. Rai’s goal is to establish an ACL registry in Nepal. Both awardees seem to have been greatly inspired by their exceptional experiences during the ISAKOS Congress and with their mentors. There is no doubt that these young researchers will contribute to the future development of clinical care and research in the near future.
02 Attendees at the ISAKOS Young Investigator award ceremony during the research symposium at the 2019 ISAKOS Congress in Cancun. The awardees are shown holding the latest ISAKOS book.
The Scientific Committee of ISAKOS has been overseeing the progress of all of the research grant winners. All of the research teams are making steady progress, and we are awaiting more reporting at future ISAKOS meetings and in related publications. Clearly, the ISAKOS grants have been an extremely effective method of supporting research for the further improvement of clinical care. We invite each of you to consider applying for these grants and are eagerly awaiting the next round of research applications.
References
1. Christiansen, et al. The scapular dyskinesis test: Reliability, agreement, and predictive value in patients with subacromial impingement syndrome. J Hand Ther. 2017 Apr – Jun;30(2):208–13. 2. Hoshino Y, et al. An image analysis method to quantify the lateral pivot shift test. Knee Surg Sports Traumatol Arthrosc. 2012 Apr;20(4):703-7. 3. Hoshino Y, et al. Quantitative evaluation of the pivot shift by image analysis using the iPad. Knee Surg Sports Traumatol Arthrosc. 2013 Apr;21(4):975-80. 4. Fernandes TL, et al. Human Synovial MSC Good Manufacturing Practices for Articular Cartilage Regeneration. Tissue Eng Part C Methods. 2018 Nov 9. doi: 10.1089/ten.TEC.2018.0219. 5. Fernandes TL, et al. Development of a Novel Large Animal Model to Evaluate Human Dental Pulp Stem Cells for Articular Cartilage Treatment. Stem Cell Rev. 2018 Oct;14(5):734-743. 6. Leyendecker Junior A, et al. The use of human dental pulp stem cells for in vivo bone tissue engineering: A systematic review. J Tissue Eng. 2018 Jan 17;9:2041731417752766. doi: 10.1177/2041731417752766. eCollection 2018 Jan–Dec. Review.
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