Page 13 - ISAKOS 2020 Newsletter Volume 2
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various injury states, and these enzymes have been shown to be directly inhibited by doxycycline. Historically, doxycycline has been used exclusively for its antimicrobial properties, but recent studies have investigated the anti-inflammatory properties of doxycycline and its effects on musculoskeletal pathologies. The purpose of this review was to describe the current use of doxycycline for its MMP-inhibitory properties in the setting of musculoskeletal pathologies. During preclinical studies, improved healing properties were noted acutely at the site of tendon injuries and chronically at the site of cartilage injuries, with decreased rates of joint-space narrowing and improved cartilage quality. The only clinical trial that has examined doxycycline use to date indicated that doxycycline can decrease the rate of joint-space narrowing in patients with osteoarthritis. Furthermore, doxycycline is well tolerated, with minimal side effects in both animal and human studies. While it can be reasonably inferred that the positive effects of doxycycline are related to its ability to inhibit MMP activity, further clinical research is warranted to investigate the use of doxycycline in orthopaedic and musculoskeletal pathologies.
Biological Augmentation to Promote Meniscus Repair: From Basic Science to Clinical Application
Courtney R. Carlson Strother, Daniel B.F. Saris, Peter Verdonk, Norimasa Nakamura, Aaron J. Krych
State of the Art
Meniscal tears range from acute tears during physical activity to chronic degenerative tears. The role of the meniscus in knee stability, load distribution, knee proprioception, and arthritis prevention has been well established, and successful repair of meniscal tears provides better clinical outcomes and protection from increased degenerative changes. Advancements in surgical techniques have demonstrated that meniscal repair is possible for tears that were previously deemed unsalvageable. In addition, the use of biological augmentation has been associated with improved rates of meniscal healing. The use of biologics is an active area of investigation, and this article reviews current methods of biological augmentation to promote meniscal healing, including biological injections, concomitant procedures, and biological membranes.
Get Published and Be Entered to Win $1,000
JISAKOS “Best Article” Competition
In honor of the ISAKOS 25th anniversary celebration, the Journal of ISAKOS will be selecting the top articles published since JISAKOS was launched in 2016. Several awards are available to win! Winners will be announced in early 2021 and recognized at the 13th Biennial ISAKOS Congress in Cape Town, South Africa.
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