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CURRENT CONCEPTS

Growth Factors (GF) and Platelet Rich

Plasma (PRP) All PRP Are Not Alike

Growth factors act synergistically. In plasma and PRP, their

concentrations are physiologically balanced.

It differs from recombinant GF which are artificially produced.
They are used in tissue research. And when one alone is
studied, biological responses can be clearly obviated.
ISAKOS ASKED

How PRP is obtained?
YOU ANSWERED
PRP is a plasma concentrate with an amount of platelets
above the serum baseline.
Results of the ISAKOS Newsletter 2014: Volume I Poll
From a fresh blood harvesting, centrifugation will insulate
PRP. Its use is mandatory bound to the patient itself, within a 1
How long is a typical work day?

short time in sterile conditions.
19% 1. 8 hours

BUT there are many companies currently claiming to have 6
kits capable of obtaining PRP or GF with and without cells. %
2. 9 hours

The Medicine Agency/Administration for each country
3. 10 hours 39%
regulates its use and makes it mandatory to use an
4. 12+ hours
36%
approved kit and to follow an approved method.

However they differ dramatically by the amount of What is the common turn 2
harvested blood, the number, speed, time and intensity of
over between cases in your
centrifugation. So the final product is fully different from one outpatient OR?
technique to another (6-11).
1.<15m 23%
The disparity is major with regards to:
2. 15 – 30m 48%
• Amountofplatelets(withdifferentconcentrations).
• Leucocytes(withorwithout,concentratedorbaseline). 19
3. 30–45m %
• Erythrocytes(withorwithout,concentratedorbaseline). 10
4. 45–60m %
• ToreleaseGF:Notactivated,activated,ifactivated
what with?
5.>60m
0%

• TypesofPresentation:Liquid,clot,membrane.
How many weeks of vacation 3
Clinical relevance
do you take annually?
The review of the current literature about the efficacy of PRP 29
is controversial.
1. 2w %

Randomized Controlled Trials: Some having reported 2. 3w 13%

positive results to shorten healing processes, while others 3. 4w 32%
found them to be useless. But beyond the efficacy of PRPs,
the difference in content, the way to apply and the tissue in 4. 5w 13
%
concern are THE major issues.
13
5. > 6w
%
PRP are not alike and PRP is not concentrated blood.
The authors believe that a concentrated amount of GF,
At what age do you plan to retire?
4
physiologically balanced, is a toolbox for injured tissue. It
should lead to an accelerated healing process although one
1.<55 0%

should be very critical about commercial claims.
2. 60
16%

Conclusion:
3. 65
35%

GF can be useful in ligaments, tendons, muscles, bone 23
and cartilage injuries in Orthopaedics and Orthopaedic 4. 70 %

Sports Medicine, shortening the repair-regeneration healing 5.>70 13%
processes or helping in case of bad evolution.
4. never
13%
The best substances to reproduce a physiological repair are

those that respect the chemical and cellular composition of
the plasma.

30 ISAKOS NEWSLETTER 2014: Volume II