2017 ISAKOS Biennial Congress ePoster #210

 

Intra-Articular Injection of Growth Hormone Compared with Hyaluronic Acid and Placebo in New Zealand Rabbit Osteoarthritis Model

Andri M. Lubis, MD, PhD, Jakarta INDONESIA
Erick Wonggokusuma, MD, Jakarta INDONESIA

Universitas Indonesia, Jakarta, Jakarta Pusat, INDONESIA

The FDA has not cleared the following pharmaceuticals and/or medical device for the use described in this presentation. The following pharmaceuticals and/or medical device are being discussed for an off-label use:

Summary

Intra articular Injection of Growth hormone shows promising result for cartilage regeneration

Abstract

Purpose

Osteoarthritis (OA), an increasingly common degenerative disease, has no medication proven to stop or reverse its degenerative process. Growth hormone (GH) can stimulate cartilage cell proliferation. This study aimed to evaluate the effect of intra-articular injection of growth hormone for osteoarthritis compared with hyaluronic acid (HA) and placebo.

Methods

and Materials

This was an experimental study with post-test only controls group design. A total of 21 male, mature New Zealand rabbits received intra-articular type II-collagenase injection for OA induction. Two weeks after injections the rabbits were randomized into three groups. The GH group received intra-articular growth hormone injection, HA group received hyaluronic acid injection and placebo group received saline injection, once weekly for three consecutive weeks. Evaluation was performed 8 weeks after treatment, clinically using lameness period, macroscopically using Yoshimi score and microscopically using Mankin score.

Results

The shortest period of lameness was found in the GH group (15.9 ± 2.12), compared to HA group (19.4 ± 1.72) and placebo (25.0 ± 2.94). There was a statistically significant difference for macroscopic scoring between groups (p=0.001), in favor of GH group. There is also significant difference between the microscopic score between groups (p=0.001), also in favor of GH group.

Conclusion

Intra-articular injection of GH showed better clinical, macroscopic and microscopic results as compared to HA and placebo in New Zealand rabbits OA model. Further research needs to be done to evaluate the efficacy and safety of intra-articular growth hormone injection for OA cases.