2017 ISAKOS Biennial Congress ePoster #226

 

Long-term Patient Reported Outcomes of Autologous Chondrocyte Implantation (ACI) with Concomitant Bone Grafting ("Sandwich-ACI") in Patients with Osteochondritis Dissecans (OCD)

Deryk G. Jones, MD, Jefferson, LA UNITED STATES
Dara Fulstone, MPH, New Orleans, LA UNITED STATES
Angie Botto-van Bemden, PhD, ATC, CSCS, Holiday, FL UNITED STATES

Ochsner Sports Medicine Institute, New Orleans, LA, UNITED STATES

FDA Status Cleared

Summary

Long-term patient reported outcomes of first and second generation Sandwich-ACI treatment in patients with osteochondritis dissecans (OCD) knee lesions demonstrating a statistically significant and clinically meaningful improvement in pain and function.

Abstract

Background

This is an analysis of the long-term patient reported outcomes collected within the prospective study comparing first and second generation (periosteal and porcine-derived type I collagen membrane, respectively) autologous chondrocyte implantation (Carticel ACI) with concomitant bone grafting ("Sandwich-ACI") osteochondral treatment in patients with osteochondritis dissecans (OCD) knee lesions.

Hypothesis

Autologous chondrocyte implantation with concomitant bone grafting ("Sandwich-ACI") improves clinical outcomes in patients with at least 1 chronic OCD lesion of the knee who failed a previous non-ACI cartilage repair treatment.

Study Design: Cohort; Level of Evidence, IV.

Methods

Forty-two patients with at least one failed non-ACI treatment for an OCD knee lesion were treated with Sandwich-ACI in this single surgeon cohort. The Visual Analog Score (VAS) pain scale, Knee Documentation Committee scale (IKDC), the Knee injury and Osteoarthritis Outcome Score (KOOS), and the Short-Form 12 Health Survey (SF-12) were used to assess patient outcomes at baseline and most recent longitudinal follow-up (MRFU). Treatment failures, serious adverse events, and subsequent surgical procedures were recorded.

Results

Sandwich-ACI osteochondral treatment was successful in this cohort of OCD patients. Mean VAS, IKDC, KOOS and SF-12 scores demonstrated a clinically meaningful and statistically significant improvement from baseline to MRFU. Patient reported knee pain during activity decreased more than 50% at MRFU.