2023 ISAKOS Biennial Congress ePoster
Safety of Single Intra-Articular Local Anesthetic Infusion in Knee Arthroscopy: An In Vivo Histological Study on Rat Cartilage
Antonios T. Kouzelis, MD, PhD, Rion, Patras GREECE
Ioannis N Vrachnis, MD, Patras GREECE
Dionysios Papachristou, Professor, Patras GREECE
Sophia Sourouni, MD,PHD, Patras GREECE
Andreas Panagopoulos, Associate Professor, Patras GREECE
Minos Tyllianakis, MD, PhD GREECE
Ioannis Gliatis, MD, PhD, Assistant Proffessor, Rion Patras, Greece GREECE
University Hospital of Patras, 1Department of Sports Medicine, University Hospital of Patras, Patras, Greece 2 Unit of Bone and Soft Tissue Studies, Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Patras, Patras, Greece , Patras, GREECE
FDA Status Not Applicable
Summary
In this experimental study we examined rat cartilage for possible histological lesions, after a single intra-articular effusion of lidocaine or ropivacaine
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Abstract
Objectives: Constant infusion of local anesthetics through pain pumps has been proved to cause chondrolysis. However, there is no general consensus regarding the safety of a single intra-articular injection of local anesthetic. In this experimental study we examined rat cartilage for possible histological lesions, after a single intra-articular effusion of lidocaine or ropivacaine
Material And Methods
Thirty-two Sprague-Dawley rats were divided in two groups of sixteen. We injected lidocaine on the left knee of the rats of the first group and ropivacaine on the rats of the second group. The right knee of the rats in both groups was used as control and an equal amount of normal saline was infused. Each group was further divided in subgroups of four, which were euthanized after one, seven, twenty-one and sixty days after the initial effusion. Knees were excised and prepared for observation in light microscope. A modified version of MANKIN score was used for cartilage damage evaluation
Results
No difference regarding cartilage damage was detected after the macroscopic observation and the examination under light microscopy between lidocaine and placebo or ropivacaine and placebo in all cases. Time elapsed since the initial injection did not affect the results.
Conclusion
Single intra-articular injection of local anesthetic did not induce any histological lesions in the rat cartilage. Further research is needed to demonstrate the safety in humans.