Summary

We found that infant and adolescent weight has a causal relationship with recurrent patellar dislocation, and that this relationship was gender independent.

Abstract

Objective

In patients with recurrent patellar dislocation, the articular cartilage is damaged, pain is experienced, and functional limitations are also experienced, further impairing the patient's life. It has been suggested in previous studies that body weight may be a risk factor for patellar dislocation or recurrent patellar dislocation; this research has mainly focused on adults, and no studies have examined the effects of birth weight and childhood weight. The aim of this study was to determine whether genetic factors can explain the relationship between birth weight, body size at age 10, and recurrent patellar dislocations using Mendelian randomization (MR).
Methods：A total of seven birth weight and body size at age 10 comparisons were identified as exposures, Analysis and extraction of 833 single nucleotide polymorphisms (SNPs) from the IEU genome-wide association studies (GWAS) database. Genetic data for recurrent patellar dislocation were obtained from the FinnGen consortium. Using the TwoSampleMR package in R, we tested the causal effect of birth weight and body size at age 10 on recurrent patellar dislocation risk.
Results：According to genetic prediction, all seven exposures were positively associated with recurrent patellar dislocation using the inverse variance weighting (IVW) method:birth weight (ebi-a-GCST007557) (OR 1.90, 95% confidence interval (Cl) 1.28-2.82, p=0.001), birth weight ( ieu-a-1083) (OR 1.96, 95% Cl 1.29-3.00, p = 0.002), Comparative body size at age 10, Males and Females (ieu-b-5107) (OR 1.92 95% Cl 1.23-3.02, p = 0.004), Comparative body size at age 10, Females (ieu-b-5108) (OR 1.62, 95% Cl 1.01-2.60, p = 0. 04), Comparative body size at age 10, Males (ieu-b-5109) (OR 1.80. 95% Cl 1.07-3.02, p = 0. 025), Comparative body size at age 10 (ukb-a-34) (OR 1.81, 95% Cl 1.16-2.82, p = 0.009) and Comparative body size at age 10 (ukb-b-4650) (OR 1.66, 95% Cl 1.09-2.54, p = 0.02). None of the analyses revealed any horizontal multidimensionality or heterogeneity.
Conclusions：There is some influence of birth weight and body size at age 10 on recurrent patellar dislocation. We found that infant and adolescent weight has a causal relationship with recurrent patellar dislocation, and that this relationship was gender independent. In light of this, weight control in children is crucial, even when it extends to gestation period, to minimize the risk factors for recurrent patellar dislocations.