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Mid-Term Results of Lipo-Amic Technique for Treatment of Focal Symptomatic Cartilage Defects in the Knee


Fabio Valerio Sciarretta, MD
ITALY

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Mid-Term Results of Lipo-Amic Technique for Treatment of Focal Symptomatic Cartilage Defects in the Knee

Fabio Valerio Sciarretta, MD, ITALY Claudio Ascani, MD, ITALY Carolina Fossati, MD, ITALY Silvana Campisi, Prof., ITALY

Clinica Nostra Signora della Mercede, Rome, ITALY

2019 Congress   Paper Abstract   2019 Congress   Not yet rated

 

Anatomic Location

Knee Patellofemoral

Anatomic Structure

Cartilage

Diagnosis / Condition

Osteoarthritis

Diagnosis Method

MRI

Sports Medicine

Outcome Studies

Treatment / Technique

Biologics Repair / Reconstruction Stem Cell Therapy

Cartilage

Cartilage Treatment

Patellofemoral

Patellofemoral Osteoarthritis

Summary: The repair of full-thickness cartilage injuries in the knee using the LIPO-AMIC technique ( Chondro-Gide collagen membrane + ADSCs ) provides good to excellent clinical improvement and MRI defect filling at mid-term follow up at three years, with results improved in respect to standard AMIC technique and comparable to matrix assisted chondrocyte implantation, at significantlly reduced costs.

Purpose

To investigate the mid-term clinical outcomes of cartilage repair using the one-stage technique of adipose tissue transfer derived stem cells in association with a collagen based scaffold (LIPO-AMIC) for treatment of full thickness cartilage injuries in the knee.

Methods

and Materials

Eighteen patients with grade III and IV cartilage injury underwent LIPO-AMIC treatment (mean age 43,9 years). Patients were followed prospectively using patient reported scoring instrument consisting of Lysholm score, the Knee Injury and Osteoarthritis Outcome Score (KOOS) and visual analogue scale (VAS) and MRI imaging. We performed comparative analysis of preoperative and postoperative scores and MRI imaging.

Results

Patients were followed at 6, 12, 24 months with final follow-up at 36 months. Patients showed relevant, immediate and durature improvement of scores already from initial follow-up. At final follow-up all scores were significantly increased (p<0.001). MRI examination showed early subchondral lamina regrowth and progressive maturation of the repair tissue and moderate to complete filling of the defects.

Conclusion

The repair of full-thickness cartilage injuries in the knee using the LIPO-AMIC technique ( Chondro-Gide collagen membrane + ADSCs ) provides good to excellent clinical improvement and MRI defect filling at mid-term follow up at three years, with results improved in respect to standard AMIC technique and comparable to matrix assisted chondrocyte implantation, at significantlly reduced costs. The literature has clearly stated that adipose tissue can represent the ideal sourse of mesenchymal stem cells since the easiness of the lipoaspirate withdrawal, the mini-invasivity of the surgical procedure, the definite chondrogenic capacity and the abundant quantities of tissue and cells that can be harvested.