2023 ISAKOS Biennial Congress ePoster
Morphologic Feature of the Proximal Tibia In Middle-Aged Women with Early Knee Osteoarthritis from Iwaki Cohort Study
Hikaru Kristi Ishibashi, MD, Hirosaki, Aomori JAPAN
Eiji Sasaki, MD, PhD, Hirosaki, Aomori JAPAN
Takahiro Tsushima, MD, PhD, Hirosaki, Aomori JAPAN
Yuka Kimura, MD, PhD, Hirosaki, Aomori JAPAN
Yasuyuki Ishibashi, MD, Hirosaki, Aomori JAPAN
Daisuke Chiba, MD, PhD, Hirosaki, Aomori JAPAN
Yuji Yamamoto, MD, Hirosaki, Aomori JAPAN
Hirosaki University, Hirosaki, Aomori, JAPAN
FDA Status Not Applicable
Summary
To investigate the influence of proximal morphology of the tibia on bone marrow lesions of EKOA from an epidemiological study in the Japanese general population.
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Abstract
Purpose
Bone marrow lesion (BML) is one of the common MRI findings in patients with early knee osteoarthritis (EKOA), that is associated with knee symptom and predict the progression of knee osteoarthritis. However, it is still unknown the relationship between BML and morphological features of the proximal tibia in EKOA. This study aimed to investigate the influence of proximal morphology of the tibia on bone marrow lesions of EKOA from an epidemiological study in the Japanese general population.
Methods
A total of 359 women (51.3 ± 11.7 years old) without radiographic knee OA, who participated in the Iwaki Health Promotion Project in both 2017 and 2019, were included. According to international EKOA criteria, participants were divided into non-OA and EKOA based on their knee symptoms. Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry. The presence of pathological lesions of cartilage, BML, attrition, meniscus, and effusion on T2-weighted fat-suppressed MRI was scored according to the Whole-Organ MRI Score system. Furthermore, medial proximal tibial angle (MPTA) on the coronal plane and medial and lateral posterior tibial slope (mPTS and lPTS) on the sagittal plane of MRI were measured based on Hudek’s method. Logistic regression analysis is performed to reveal the relationship among BMD, proximal tibia angles, and the presence of BML in the EKOA and non-OA groups.
Results
A total of 54 out of 359 (15%) participants were classified into EKOA. Mean BMD was 0.618 ± 0.100 g/cm2. The prevalence of cartilage, bone marrow, attrition, meniscus lesions, and effusion in the EKOA group were 59.3%, 44.4%, and 14.8%, 27.8%, 42.6%, and higher than those in the non-OA group. Mean MPTA, mPTS, and lPTS were 86.0±1.8°, 3.6 ± 3.3°, and 3.5 ± 3.2°, respectively. There was no difference in these proximal tibia angles between non-OA and EKOA. Furthermore, mPTS and lPTS were not related to age. Regression analysis showed that BMD was not related to MPTA, mPTS, and lPTS. In contrast, mPTS (p=0.040) and MPTA (p=0.021) were negatively correlated with the presence of BML only in the EKOA group.
Conclusion
The prevalence of BML was higher in those with EKOA, and that was correlated with varus deformity (smaller MPTA) and increase of posterior tibial slope (larger mPTS) in middle-aged women. These results revealed that three-dimensional deformity of the proximal tibia had already occurred from the stage of EKOA.