Background
Rotator Cuff Tendinopathy is an inflammatory and multifactorial degenerative disease. Its manifestation reduces the quality of life of patients. Treatment begins clinically aiming for symptom relief. However, the literature shows that up to 67% of cases remain unsuccessful and may evolve with the need for surgical intervention. In this scenario, the injection of microfragmented adipose tissue is considered an emerging regenerative treatment. Methodology: This is a case series with 01 year follow-up, of patients with rotator cuff tendinopathy, aged between 40 and 67 years, treated at a Public University Hospital in Brazil, who underwent a shoulder injection procedure of the microfragmented adipose tissue obtained from abdominal liposuction. According to the exclusion criteria, individuals who performed other invasive therapeutic methods, who suffered some shoulder trauma, or who were diagnosed with systemic diseases with joint involvement during the follow-up period were removed from the study. Clinical outcomes of function and pain were evaluated through the application of UCLA, SPADI and CMS questionnaires, which were applied before the procedure and after 7 days, 1 month, 3 months, 6 months, and 1 year of the procedure. Results: The mean age of the population was 50 years (N = 12), with females prevailing (58.3%) and with an equal distribution regarding the laterality of the affected shoulder (7 right and 7 left), with a mean BMI of 28.1. The UCLA questionnaire showed an improvement of 66% (11.2 points) in the 1-year period. Similarly, after 1 year of the procedure, there was an improvement of 76% (44.1 points) in the SPADI questionnaire. The CMS questionnaire, in turn, showed significant improvement only between the 7-day and 1-month evaluation (57 vs. 71.1 points). It was possible to observe strong correlations between the questionnaires in the 1-year evaluation after the procedure (UCLA vs. SPADI = -0.901; UCLA vs. CMS = 0.917; SPADI vs CMS = -0.955). Conclusion: The injection of microfragmented adipose tissue proved to be effective in reducing pain and increasing functionality, besides being applicable in a public health context.