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Steadman Philippon Research Institute Vail, Colorado UNITED STATES I am the Chief Scientific Officer (CSO) and Director of the Center for Regenerative and Personalized Medicine (CRPM) at the Steadman Philippon Research Institute (SPRI) in Vail, Colorado. I am also an Affiliate faculty, Department of Clinical and Biomedical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins Colorado where I direct a research team of 4 Principal Investigators. I served as Professor, Distinguished Chair in Orthopaedic Research in the Department of Orthopaedic Surgery at the University of Texas Health Science Center at Houston (UTHealth) McGovern Medical School. Between 1995-2015, I held the Henry J. Mankin Endowed Chair in the Department of Orthopaedic Surgery and was the Director of the Stem Cell Research Center (SCRC); held numerous secondary appointments at the University of Pittsburgh and was also the deputy director for Cellular Therapies at the McGowan Institute for Regenerative Medicine. I have extensive knowledge in the areas of gene therapy, tissue engineering, and regenerative medicine applications based on the use of muscle-derived stem/progenitor cells (MDSCs). The muscle-derived stem cells that have been isolated by my team are currently undergoing clinical trials for treatment of stress urinary incontinence (SUI) and myocardial infarction. More than 700 women suffering with SUI in Canada and the U.S. have volunteered for this stem cell therapy (Phase III Clinical Trial). My team and I have published over 475 peer reviewed papers, over 100 reviews/book chapters, and have over 1000 abstracts accepted for presentation at national and international conferences (Citations 50278; h-index:118, i10-index:401). Our current major research interests include: muscle stem cells isolation & characterization; bone & articular cartilage regeneration and repair; senotherapeutics in musculoskeletal repair, alleviation of muscle weakness in Duchenne Muscular Dystrophy (DMD); cardiac and skeletal muscle injury repair, regeneration, and fibrosis prevention; peripheral nerve regeneration; healthy aging, and the use of adult stem cells as a source for paracrine factors to alleviate the phenotypic changes associated with natural and accelerated aging. The focus of my laboratory is to develop biological medicine approaches to improve musculoskeletal tissue repair after injury, disease and aging. We are using a variety of technology that falls into four different categories which include: Biologics (adult stem cells which include muscle derived stem cells, adipose derived stem cells as well as Bone Marrow Aspirate and Platelet Rich Plasma); Regenerative Medicine approaches (gene therapy approaches, CRISPR-Cas9, protein delivery like coacervate, microspheres, PA-nanofibers and magnetic nanoparticles); Therapeutics (FDA approved drugs such as anti-fibrotic agents, pro-angiogenic agents, telomerase activity, (hTERT), senotherapeutics like senolytic and senomorphic drugs); Animal Modelling (dystrophic and progeria mice models, super healer mice (MRL/MpJ), osteoarthritis model/microfracture, tibia fracture, calvarial defect and ovariectomy). My recent research has led to several Clinical Trials using Losartan and fisetin for treatment of different diseases.
Patient Satisfaction And Donor Site Morbidity Following Arthroscopic Superior Capsule Reconstruction Using Fascia Lata Autograft For Irreparable Rotator Cuff Tears Akihiko Hasegawa, MD, PhD, JAPANMid-term outcomes of arthroscopically assisted lower trapezius tendon transfer with associated partial cuff repair in the treatment of functional irreparable posterior-superior rotator cuff tears. Gia Rodriquez Vaquero, MD, MSc, SPAINFunctional Outcomes And Radiological Cuff Tear Healing In Arthroscopic Single Row Rotator Cuff Repair In Patients Of Age More Than 65: A Retrospective Case Study Jaimeen Pravinkumar Jesalpura, MD, INDIASuperior Capsular Reconstruction With the Distal Fascia Lata Tomohiko Sano, MD, PhD, JAPANNo Influence of Biceps Sheath Fluid on Patient-Reported Outcome in Individuals with Symptomatic Isolated Supraspinatus Tendon Tears Jumpei Inoue, MD, UNITED STATESEffectiveness Of Intraoperative Glenohumeral Joint Injection Of Hyaluronate/Carboxymethyl Cellulose In Arthroscopic Rotator Cuff Repair Supanut Klaiudom, MD, THAILANDMachine-Learning Models For Shoulder Rehabilitation Exercises Classification Using A Wearable System Umile Giuseppe Longo, MD, MSc, PhD, Prof., ITALYBiological Augmentation In Revision Surgery: A Pilot Study Of The Effect Of A Bioinductive Collagen Patch In Patients With Rotator Cuff Retear And A Previous Arthroscopic Rotator Cuff Repair. Cristina Delgado, MD, PhD, SPAINPrecision Medicine for Patients with Rotator Cuff Diseases: Relationship Between Clinical Scores and Shoulder Kinematic Parameters Umile Giuseppe Longo, MD, MSc, PhD, Prof., ITALYDoes Long Head Biceps Augmentation Improve The Biomechanics In Anterior L-Shaped Supraspinatus Tendon Tear?: A Cadaveric Study Nadhaporn Saengpetch, MD, THAILANDAdding an Erector Spinae Plane Catheter Block AfteraAn Interscalene Nerve Block Significantly Improves Pain Relief and Decreases Opioid Use Following Arthroscopic Rotator Cuff Repair Chih-Kai Hong, MD, TAIWAN“Surviving the Dip” after Subacromial Balloon Spacer Implantation for Massive Rotator Cuff Tear Treatment: A Retrospective Case Series John Nyland, EdD, DPT, UNITED STATESEvaluation Of The Relationship Between Rotator Cuff Tear And Humeral Shaft-Neck Angle Abdurrahman Aydın, MD, TURKEYImpact Of Rotator Cuff Repair Surgery And Rehabilitation On Anxiety And Depression As Assessed By Hads And Montgomery Depression Scale And Its Correlation With Functional Outcomes . Prince Shanavas Khan, D' ORTHO, M.S. ORTHO, INDIACan Fatty Infiltration Percentages On MRI Predict Irreparable Cuff Tears? Gregory A. Hoy, FRACS, FAOrthA, FACSP, FASMF, AUSTRALIAThe Effects of Arthroscopic Rotator Cuff Repair on Human Sexual Activity Tarek M. T. Ghandour, MD, EGYPTHuman Dermal Allograft Augmentation In Rotator Cuff Repair: Is There Patch Integration? Jonas Fernandez, MD, Ms Orth, MALAYSIAThe investigation to clarify the most effective rotatory range of cuff exercise for making the good force couple mechanism Yasunari Fujii, MD, JAPANMihata Superior Capsular Reconstruction With Fascia Lata Auto Graft For Irreparable Rotator Cuff Tears In The Usa: Early Mri Results. Paul Byron Roache, MD, UNITED STATESInnovative Approach to Rotator Cuff Assessment: Introducing The Muscle Efficiency Index and Its Role in Injury Analysis and Shoulder Biomechanics Majd Mzeihem, MD, UNITED STATESPersistent Subacromial Bursal Effusion Leads to Inferior Patient-Reported Outcome in Individuals with Symptomatic Isolated Supraspinatus Tendon Tears Jumpei Inoue, MD, UNITED STATESClinical Outcome And Long Term Follow-Up After Failed Arthroscopic Repair Of Massive Rotator Cuff Tear – Who Can Go To Conservative Treatment Instead Of Revision? Hsuan‑Hsiao Ma, MD, TAIWANBio-Ravioli: A Novel Surgical Technique For Biologic Augmentation Of Rotator Cuff Repair Andrea Pratobevera, MD, ITALYImpact Of Remplissage On Rotator Cuff Muscle Elasticity And Early Postoperative Stiffness In Anterior Shoulder Instability Patients. Yoshimasa Saigo, MD, JAPANMuscle Err? Activation Mitigates Muscle Fibrosis And Fatty Infiltration After Rotator Cuff Injury Johnny Huard, PhD, UNITED STATESCan Popular AI Large Language Models Provide Reliable Answers to Frequently Asked Questions About Rotator Cuff Tears? Ulaş Can Kolaç, MD, TURKEYEvaluation Of Clinico-Radiological Outcomes Of Arthroscopic Repair Of Rotator Cuff Tear With Bioaugmentation Using Autologous Platelet Rich Plasma Rohan Goel, MBBS, MS (Ortho), INDIAEnhancing Rotator Cuff Repair With Dermal Allograft Augmentation: Healing & Patient Outcomes Reza Ojaghi, MD MSc FRCSC, UNITED STATESClinical Outcomes of Arthroscopic Superior Capsular Reconstruction Using Long Head of the Biceps With Rotator Cuff Repair Daichi Morikawa, MD, PhD, JAPANAaos Orthoinfo Provides More Accessible Information Regarding Rotator Cuff Surgery Than Chatgpt Brian Forsythe, MD, UNITED STATESTear Characteristics Influence Tendon Retraction And Postoperative Outcomes Following Arthroscopic Repair Of Acute Traumatic Rotator Cuff Tears Albert Lin, MD, UNITED STATESComparison of clinical outcome and cuff repair integrity between arthroscopic rotator cuff repair with and without superior capsular reconstruction for reinforcement Katsutoshi Miyatake, MD, PhD, JAPANPredicting Risk Factors For Retear In Massive Rotator Cuff Double Row Repair- Using Multiple Regression Analysis And Follow Up MRI Study Rajagopalakrishnan Ramakanth, D.ortho, DNB(ortho), D.SICOT, INDIAPatients With Untreated Long Head Of The Biceps Tendon Pathology During Rotator Cuff Repair Have Worse Objective And Subjective Outcomes Chukwudi Onyeukwu, MD, MS, UNITED STATES
2025 Congress ePoster Presentation PDF 2025 Not yet rated
Shoulder Rotator Cuff Tears Repair / Reconstruction Arthroscopy Autograft Biologics Allograft Impingement Instability
BMAC and Hyaluronan Scaffold Alberto Gobbi, MD, FRACS, ITALYStem Cell Therapy in Sports Medicine Chih-Hwa Chen, MD, Prof., TAIWANGrowth Factors: How to Prepare and Use Ramon Cugat Bertomeu, MD, PhD, SPAINBasic Science and New Therapies in Sport Medicine Johnny Huard, PhD, UNITED STATESPractical Applications of Growth Factors, Cells, and Novel Therapies in Sports Medicine Giuseppe Filardo, MD, PhD, MBA, Prof., SWITZERLANDNovel Therapies - Adipose Tissue, Cells, Umbilical Cord and Amniotic ET Rodrigo M. Mardones, MD, CHILEDiscussion Ramon Cugat Bertomeu, MD, PhD, SPAIN
2019 Congress Symposium Video 88 minutes group rating (1)
Ramon Cugat Bertomeu, MD, PhD, SPAIN
Knee Cartilage Ligaments Meniscus Osteoarthritis Muscle Bones Trauma Arthritis Patellofemoral
Gene Expression of Healing Factors as a Predictor to Treat Anterior Cruciate Ligament injuries Diego Costa Astur, MD, PhD, BRAZILKnee Ostoearthritis: Cell Therapy and Exercises Alter Gene Expression of Inflammatory Molecules and Extracellular Matrix Mario Ferretti, MD, PhD, BRAZILOverview of Genetic Risk Factors in ACL Injury Willem M. van der Merwe, MBChB, FCS(SA)Ortho, SOUTH AFRICAGenetics in Knee Injuries Johnny Huard, PhD, UNITED STATESDiscussion Johnny Huard, PhD, UNITED STATES
2019 Congress Symposium Video 25 minutes Not yet rated
Willem M. van der Merwe, MBChB, FCS(SA)Ortho, SOUTH AFRICA
Knee Ligaments Instability Basic Science ACL Evidence Based Medicine Allograft Arthroscopy Autograft Repair / Reconstruction
2019 Congress Paper Abstract Web Not yet rated
Patrick S. Buckley, MD, UNITED STATES
Elbow / Wrist / Hand Ligaments Tears Basic Science Sport Specific Injuries Repair / Reconstruction Medial Collateral Ligament
2017 Congress Paper Abstract Web rating (1)
Christopher D. Harner, MD, FAOA, UNITED STATES
Basic Science Biologics Stem Cell Therapy
Updates on the Latest Cell Therapy for Articular Cartilage Repair Johnny Huard, PhD, UNITED STATESWhat We Know and What We Don't Know Adam W. Anz, MD, UNITED STATESDiscussion Frank Barry, IRELAND
2015 Congress Symposium Video 61 minutes Not yet rated
Johnny Huard, PhD, UNITED STATES
Rehabilition / Physical Therapy Repair / Reconstruction
2015 Congress Paper Abstract Web rating (1)
Makoto Kobayashi, MD, PhD, JAPAN
Muscle Basic Science Stem Cell Therapy
Yohei Kawakami, MD, PhD, JAPAN
Knee Ligaments Basic Science Biologics Stem Cell Therapy ACL
2013 Congress Paper Abstract Web Not yet rated
Koji Takayama, MD, PhD, JAPAN
Knee Ligaments Stem Cell Therapy ACL
No Financial Conflicts to Disclose