The chondral lesion and osteoarthritis are conditions associated with an economic burden, since if left untreated may cause changes in the biomechanics of the joint and result in several injuries considered highly disabling to the individual. Mesenchymal Stromal Cells (MSCs) have the immunomodulatory capacity and paracrine signaling that are useful for tissue bioengineering to treat bone and cartilage injuries. The articular cartilage is a viscoelastic material that can undergone structural and compositional changes; therefore, it is important to assess the physical properties of the tissue through mechanical evaluation. The differential of this study is that the cell culture process was carried out under Good Manufacturing Practices (GMP) conditions for use in humans. Objective: This study aims to describe biomechanical analysis for cartilage restoration by tissue engineering and cell therapy treatments in a GMP translational large animal model Methods: A controlled experimental study in fourteen Brazilian miniature pigs was performed, using scaffold-free Tissue Engineering Construct (TEC) from dental pulp and synovial MSCs with 6 months follow-up. To compare the cartilage with and without TEC, three stress-strain cycles were performed in the indentation test, followed by maximum compression, as well as Finite Element (FE) model using ANSYS R17.2 to simulate the osteochondral block and characterize its properties Results: Indentation and maximum compression tests assessed the properties of the solid matrix and mechanical proprieties of the tissue repair in control and treatment groups. The indentation response showed the hysteresis phenomenon evidencing the viscoelastic property of the articular cartilage. The Young Modulus (YM) determined at 5% strain were 0.72 ± 0.47 and 1.23 ± 0.82 for the control and treatment groups, respectively, with statistical significance (p < 0.05). The FE analysis showed the force distribution in the osteochondral block Conclusion: The proposed method allowed feasible and capable evaluation of the physical properties of the articular cartilage restoration. A higher YM value in the treated group might indicate superior repair. The FE model allowed for better visualization of the structure when undergoing compression.

Long-Term Clinical Outcomes of One-Stage Cartilage Repair in the Knee Using Hyaluronic Acid-Based Scaffold with Bone Marrow Aspirate Concentrate (Ha-BMAC): Thirteen Year Follow-Up ePoster Presentation Alberto Gobbi, MD, FRACS, ITALY Katarzyna Herman, MD, POLAND Dawid Szwedowski, MD, PhD, POLAND Anna Montagna, PhD, ITALY Leandra Bizocco, Dr., ITALY
Xenogeneic Cartilage Scaffold as a Promising Alternative for Full-Thickness Cartilage Defect Treatment: A Prospective Pilot Study on Clinical Outcome of Novel Bovine Cartilage Scaffold ePoster Presentation Dwikora Novembri Utomo, MD, PhD, INDONESIA Kukuh Dwiputra Hernugrahanto, MD, INDONESIA Lukas Widhiyanto, MD, PhD, INDONESIA Jifaldi Afrian Maharaja Dinda Sedar, MD, INDONESIA Dewi Masrifah Ayub, MD, INDONESIA Nicolaas C. Budhiparama, MD, PhD (LUMC, NL), PhD (UGM, ID), FICS, Prof., INDONESIA
Early Outcomes and Return to Work After Cartilage Repair in a Workers’ Compensation Population ePoster Presentation John G. Lane, MD, UNITED STATES Tyler Jordan Wipf, PA-C, UNITED STATES
The Effect Of Injection of Secretome of Umbilical Cord Mesenchymal Stem Cells in Articular Cartilage Repair in Sheep Model ePoster Presentation Andri M. Lubis, Prof, MD, PhD, INDONESIA Andi Praja Wira Yudha Luthfi, MD, INDONESIA Jeanne Adiwinata Pawitan, Prof., INDONESIA Bambang Pontjo Priosoeryanto, Prof., INDONESIA Anissa Feby Canintika, MD, INDONESIA
Outcomes Following Gel-Based Autologous Chondrocyte Implantation for Articular Cartilage Defects of the Knee ePoster Presentation Dinshaw Pardiwala, MS(Orth), DNB(Orth), FCPS, INDIA Sachin Tapasvi, MBBS, MS, DNB, FRCS, INDIA Ashish Sudhakar Babhulkar, D(ortho),DNB(ortho),FRCS,MCH, INDIA David V. Rajan, MS(Orth), MNAMS(Orth), FRCS(G), INDIA Deepak Chaudhary, MD, INDIA Abhay Dattaram Narvekar, MS (Orth), INDIA Parag Sancheti, FRCS (Ed),MS(ORTH), DNB(ORTH), MCh(UK),Ph.D(UK), INDIA
Effectiveness Of Intra-Articular Injection Of Platelet-Derived Extracellular Vesicles For Treating Patients With Mild Or Moderate Knee Osteoarthritis ePoster Presentation Jonas Fernandez, MD, Ms Orth, MALAYSIA
Effect Of Patient History Factors On Meniscus Repair Outcomes ePoster Presentation Nathalie Sackey, BS, UNITED STATES Parker Cavendish, BS, UNITED STATES Eric Milliron, BS, UNITED STATES James C. Kirven, BS, UNITED STATES Spencer E. Talentino, MD, UNITED STATES Charles Qin, MD, UNITED STATES Ryan H. Barnes, MD, UNITED STATES Robert A Magnussen, MD, MPH, UNITED STATES Christopher C. Kaeding, MD, UNITED STATES David C. Flanigan, MD, UNITED STATES
Costal Chondrocyte-Derived Pellet-Type Scaffold-Free Autologous Chondrocyte Implantation For Osteochondral Defects With Up To 10-Mm Depths ePoster Presentation Kyoung Ho Yoon, MD, PhD, Prof., KOREA, REPUBLIC OF Hee Sung Lee, MD, KOREA, REPUBLIC OF Cheol Hee Park, MD, PhD, KOREA, REPUBLIC OF Sung Hyun Hwang, MD, KOREA, REPUBLIC OF
Medial Opening Wedge High Tibial Osteotomy Affects More than Just the Knee: A Study Looking at Changes in the Knee, Hip and Ankle Joints During Gait ePoster Presentation Sarah Bolton, MBBS, FRCS (Orth), AUSTRALIA David A. Parker, MBBS, BMedSc, FRACS, AUSTRALIA Myles R. J. Coolican, FRACS, AUSTRALIA Brett A. Fritsch, MBBS BSc(Med), FRACS, FAOrthA, AUSTRALIA Alexander S. Nicholls, MSc, FRACS, AUSTRALIA Yoong Lim, BEng, PhD, AUSTRALIA
Atelocollagen-associated Autologous Chondrocyte Implantation for the Repair of Large Cartilage Defects of The Knee: Results at Three to Seven Years ePoster Presentation Takuma Kaibara, MD, JAPAN Eiji Kondo, MD, PhD, JAPAN Masatake Matsuoka, PhD, JAPAN Koji Iwasaki, MD, PhD, JAPAN Tomohiro Onodera, MD, PhD, JAPAN Keita Sakamoto, MD, JAPAN Yoshitaka Oda, MD., PhD, JAPAN Zen-ichi Tanei, MD., PhD, JAPAN Daisuke Momma, PhD, JAPAN Shinya Tanaka, MD., PhD., Prof. , JAPAN Norimasa Iwasaki, MD, PhD, JAPAN
Functional Midterm Outcome Of Autologous Chondrocyte Implantation With Spheroids Combined with Simultaneous Autologous Bone Grafting for Treating Osteochondral Defects of the Knee Joint ePoster Presentation Stephan Oehme, MD, GERMANY Sophie Krafzick, cand. med., GERMANY Tobias Winkler, Prof., MD, GERMANY Philipp Damm, Dr.-Ing., GERMANY Tobias M. Jung, MD, GERMANY
Return to Pivoting Sports after Cartilage Repair Surgery of the Knee: A Scoping Review ePoster Presentation Seikai Toyooka, MD, PhD, , JAPAN Gilbert Moatshe, MD, PhD, NORWAY Andreas Persson, MD, NORWAY Lars Engebretsen, MD, PhD, NORWAY
Outcomes of Operative Fixation of Loose Trochlear Osteochondral Defects Compared Based On Skeletal Maturity ePoster Presentation Galo Bustamante, BS, UNITED STATES Amogh Iyer, BS, UNITED STATES Eric Milliron, BS, UNITED STATES Parker Cavendish, BS, UNITED STATES Spencer E. Talentino, MD, UNITED STATES James C. Kirven, BS, UNITED STATES Charles Qin, MD, UNITED STATES Ryan H. Barnes, MD, UNITED STATES Robert A. Duerr, MD, UNITED STATES Robert A Magnussen, MD, MPH, UNITED STATES Christopher C. Kaeding, MD, UNITED STATES David C. Flanigan, MD, UNITED STATES
Effects of A Medial Opening-Wedge Distal Tibial Osteotomy Using Hemicallotasis (OWDTO-HCO) on Articular Cartilage of The Proximal Tibiofibular Joint ePoster Presentation Eiichi Nakamura, MD, PhD, JAPAN Hiroaki Nishioka, MD, PhD, JAPAN Nobukazu Okamoto, MD, PhD, JAPAN Tetsurou Masuda, MD, PhD, JAPAN Satoshi Hisanaga, MD, PhD, JAPAN Yasunari Oniki, MD, PhD, JAPAN
Preoperative Medial Tightness And Narrow Medial Joint Space Are Predictive Factors for Lower Extremity Alignment Change Toward Varus after Open Wedge High Tibial Osteotomy ePoster Presentation Sung-Sahn Lee, MD., PhD., KOREA, REPUBLIC OF Young Keun Lee, MD, KOREA, REPUBLIC OF Dong Jin Ryu, MD, PhD., KOREA, REPUBLIC OF Eui Yub Jung, MD, KOREA, REPUBLIC OF Joon Ho Wang, MD, PhD, KOREA, REPUBLIC OF
A Systematic Review Of Rehabilitation Protocols Following Matrix-Assisted Autologous Chondrocyte Implantation ePoster Presentation Jaydeep Dhillon, BS, UNITED STATES Sydney M Fasulo, MD, UNITED STATES Matthew J. Kraeutler, MD, UNITED STATES John W. Belk, BA, UNITED STATES Patrick C. McCulloch, MD, UNITED STATES Anthony Scillia, UNITED STATES
MACI Case Series With Bone Involvement Requiring Autologous Bone Grafting ePoster Presentation Deryk G. Jones, MD, UNITED STATES Bhumit Desai, MD, UNITED STATES Jordan Nester, MD, UNITED STATES Graylin Jacobs, CRC, UNITED STATES Brian M Godshaw, MD, UNITED STATES
A Comparative Match-Pair Analysis Using Adipose-Derived Mesenchymal Stem Cells Plus Biplanar Tibial Open-Wedge Osteotomy In Treatment Of Varus Knee Osteoarthritis ePoster Presentation Matteo Baldassarri, MD, ITALY Diego Ghinelli, ITALY Alessandro Parma, MD, ITALY Sarino Ricciardello, MD, ITALY Luca Perazzo, MD, ITALY Roberto Buda, Prof., ITALY
Surgical Management Of Osteochondritis Dissecans Of The Patellofemoral Joint ePoster Presentation Ryo Kanto, MD, JAPAN Tomoya Iseki, MD, PhD, JAPAN Hiroshi Nakayama, MD., Ph.D., JAPAN Shintaro Onishi, MD, PhD, JAPAN Yoshitaka Nakao, MD, JAPAN Shota Morimoto, MD, PhD, JAPAN Shinichi Yoshiya, MD, JAPAN Toshiya Tachibana, MD, PhD, JAPAN
The Effects Of Running On The Development Of Knee Osteoarthritis: An Updated Systematic Review ePoster Presentation Jaydeep Dhillon, BS, UNITED STATES Matthew J. Kraeutler, MD, UNITED STATES John W. Belk, BA, UNITED STATES Anthony Scillia, UNITED STATES Eric C. McCarty, MD, UNITED STATES Jeremy K Ansah-Twum, BS, UNITED STATES Patrick C. McCulloch, MD, UNITED STATES
Costal Chondrocyte-Derived Pellet-Type Autologous Chondrocyte Implantation vs. Microfracture for Repair of Articular Cartilage Defects ePoster Presentation Dae Keun Suh, MD, PhD, KOREA, REPUBLIC OF Kyoung Ho Yoon, MD, PhD, Prof., KOREA, REPUBLIC OF Cheol Hee Park, MD, PhD, KOREA, REPUBLIC OF Sang-Gyun Kim, MD, PhD, KOREA, REPUBLIC OF Jae-Young Park, MD, KOREA, REPUBLIC OF Yoon-Seok Kim, MD, KOREA, REPUBLIC OF Hee Sung Lee, MD, KOREA, REPUBLIC OF Sung Hyun Hwang, MD, KOREA, REPUBLIC OF Bo Seung Bae, MD, KOREA, REPUBLIC OF
“Nuts In Jelly” Mosaicplasty for Medium to Large Chondral Defects of Knee – Functional Outcomes Up to 5 Years Follow Up ePoster Presentation Girinivasan Chellamuthu, MBBS, MS Ortho, FIOT, FASM, INDIA Santosh Sahanand Kulasekaran, MBBS,MS(ortho), INDIA David V. Rajan, MS(Orth), MNAMS(Orth), FRCS(G), INDIA
Imaging Evaluation of Physical Activity on Knee Articular Cartilage ePoster Presentation Marcus Vinicius Danieli, MD, PhD, BRAZIL João P.F. Guerreiro, MD, PhD, BRAZIL Felipe Santos LIma, MD, BRAZIL Luan Possani Rodrigues, MD, BRAZIL Jan Walter Stegmann Filho, MD, BRAZIL Arthur Gomes Rossitto, MD, BRAZIL Arnaldo Eder Kist, MD, BRAZIL João Luiz Francisconi, MD, BRAZIL Paulo Roberto Bignardi, PhD, BRAZIL
Use of Fresh Frozen Osteochondral Allograft for the Treatment of Cartilage Defects of the Knee Functional Results And Failure Rate at a Mean Seven-Year Follow-Up ePoster Presentation Pablo Dardanelli, MD, ARGENTINA Nicolas Molho, MD, ARGENTINA Catalina Larrague, MD, ARGENTINA Juan Pablo Zicaro, MD, ARGENTINA Carlos H. Yacuzzi, MD, ARGENTINA Matias Costa-Paz, MD, PhD, ARGENTINA
A Prospective Observational Study Of Functional Outcome Of Leucocyte Poor Platelet Rich Plasma Therapy In Mild To Moderate Osteoarthritis Of Knee ePoster Presentation Umesha Chowdaiah, MBBS, D.Ortho, DNB (Ortho), INDIA
Safety of Single Intra-Articular Local Anesthetic Infusion in Knee Arthroscopy: An In Vivo Histological Study on Rat Cartilage ePoster Presentation Antonios T. Kouzelis, MD, PhD, GREECE Ioannis N Vrachnis, MD, GREECE Dionysios Papachristou, Professor, GREECE Sophia Sourouni, MD,PHD, GREECE Andreas Panagopoulos, Associate Professor, GREECE Minos Tyllianakis, MD, PhD, GREECE Ioannis Gliatis, MD, PhD, Assistant Proffessor, GREECE
Cartilage Repair of the Tibiofemoral Joint with Versus Without Concomitant Osteotomy: A Systematic Review of Clinical Outcomes ePoster Presentation Jaydeep Dhillon, BS, UNITED STATES Matthew J. Kraeutler, MD, UNITED STATES Sydney M Fasulo, MD, UNITED STATES Mary K. Mulcahey, MD, UNITED STATES Anthony Scillia, UNITED STATES Patrick C. McCulloch, MD, UNITED STATES
Reliability of Preoperative Planning Method That Considers Latent Medial Joint Laxity In Medial Open-Wedge Proximal Tibial Osteotomy ePoster Presentation Dong Jin Ryu, MD, PhD., KOREA, REPUBLIC OF Sung-Sahn Lee, MD., PhD., KOREA, REPUBLIC OF Eui Yub Jung, MD, KOREA, REPUBLIC OF Joon Ho Wang, MD, PhD, KOREA, REPUBLIC OF
A Systematic Review of Randomised Controlled Trials Evaluating Injectable Orthobiologics for Knee Osteoarthritis: The Relationship Between Clinical Outcomes, Risk of Bias and Impact Factor Of Journal ePoster Presentation Patrick G Robinson, MBChB, MRCS, MS, MBA, UNITED KINGDOM Fares S. Haddad, MCh(Orth), BSc, FRCS(Orth), UNITED KINGDOM Robert F. LaPrade, MD, PhD, UNITED STATES Iain Robert Murray, MD, PhD, UNITED KINGDOM
A Novel Locking Plate System With Cannulated Screws For Medial Opening Wedge High Tibial Osteotomy: Clinical And Radiological Comparisons With A Conventional Locking Plate ePoster Presentation Eiji Kondo, MD, PhD, JAPAN Koji Yabuuchi, MD, JAPAN Koji Iwasaki, MD, PhD, JAPAN Masatake Matsuoka, PhD, JAPAN Tomohiro Onodera, MD, PhD, JAPAN Daisuke Momma, PhD, JAPAN Tomonori Yagi, MD, PhD, JAPAN Kazunori Yasuda, MD, PhD, Prof., JAPAN Norimasa Iwasaki, MD, PhD, JAPAN
RNA Sequencing Analysis of Neotissue Following Combined Autologous Chondrocyte Implantation with High tibial Osteotomy for Femoral Cartilage Injury with Varus Deformity ePoster Presentation Tomoya Iseki, MD, PhD, JAPAN Ryo Kanto, MD, JAPAN Shintaro Onishi, MD, PhD, JAPAN Yoshitaka Nakao, MD, JAPAN Nobuyoshi Suzuki, MD, JAPAN Takuya Iseki, MD, PhD, JAPAN Shota Morimoto, MD, PhD, JAPAN Hiroshi Nakayama, MD., Ph.D., JAPAN Toshiya Tachibana, MD, PhD, JAPAN
Lateral Tibial Cartilage Slope and Meniscal Geometry in Patients With and Without ACL Injury ePoster Presentation Steffen Sauer, MD, DENMARK George Tsironis, MD, GERMANY
Maci Case Series in Patients With Multiple Osteochondral Defects ePoster Presentation Deryk G. Jones, MD, UNITED STATES Bhumit Desai, MD, UNITED STATES Jordan Nester, MD, UNITED STATES Graylin Jacobs, CRC, UNITED STATES Brian M Godshaw, MD, UNITED STATES
Novel Solution Using Viable Cartilage Allograft For Focal Cartilage Defects ePoster Presentation Deryk G. Jones, MD, UNITED STATES Bhumit Desai, MD, UNITED STATES Graylin Jacobs, CRC, UNITED STATES Gerard Karl Williams Jr., MD, UNITED STATES Walter Stephen Choate, MD, UNITED STATES Scott C Montgomery, MD, UNITED STATES Brian M Godshaw, MD, UNITED STATES Misty Suri, MD, UNITED STATES
Maci Case Series in Patients Aged 40 to 55 ePoster Presentation Deryk G. Jones, MD, UNITED STATES Bhumit Desai, MD, UNITED STATES Jordan Nester, MD, UNITED STATES Graylin Jacobs, CRC, UNITED STATES Brian M Godshaw, MD, UNITED STATES
Particulated Costal Allocartilage with Microfracture vs. Microfracture Alone: A Multicenter, Prospective, Randomized, Participant- and Rater-Blinded Study ePoster Presentation Kwangho Chung, MD, KOREA, REPUBLIC OF Min Jung, MD, PhD, KOREA, REPUBLIC OF Sanghoon Park, MD, KOREA, REPUBLIC OF Ki-Mo Jang, MD, PhD, Prof., KOREA, REPUBLIC OF Chong-Hyuk Choi, MD, PhD, KOREA, REPUBLIC OF Sung-Hwan Kim, MD, PhD, KOREA, REPUBLIC OF
Tissue Engineering for Cartilage Repair: Pre-Clinical Trial Evaluation Methods ePoster Presentation Joao Paulo Cortez Santanna, MD, MSc, BRAZIL Tiago Lazzaretti Fernandes, MD, PhD, MSc, Post-Doctorate, BRAZIL Rafaella Rogatto De Faria, PhD, BRAZIL Vera Demarchi Aiello, MD, PhD, BRAZIL Carla Pinheiro, MSc, BRAZIL Daniela Franco Bueno, DDS, PhD, BRAZIL Arnaldo J. Hernandez, MD, PhD, BRAZIL
Cellular Behavior In A Partial-Thickness Cartilage Defect Under Hydrostatic Pressure and/or Strain Mimicking Weight-Bearing and Joint-Loading ePoster Presentation Chilan Leite, MD, PhD, UNITED STATES Christian Lattermann, MD, UNITED STATES Shuichi Mizuno, Ph.D., UNITED STATES

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Tissue Engineered Construct Showed Better Biomechanical Results for Articular Cartilage Restoration in a GMP Pre-Clinical Study

Tissue Engineered Construct Showed Better Biomechanical Results for Articular Cartilage Restoration in a GMP Pre-Clinical Study

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Tissue Engineered Construct Showed Better Biomechanical Results for Articular Cartilage Restoration in a GMP Pre-Clinical Study

Tissue Engineered Construct Showed Better Biomechanical Results for Articular Cartilage Restoration in a GMP Pre-Clinical Study

Introduction

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