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Risk Factors Affecting the Survival Rate of Collagen Meniscus Implant (CMI) For Partial Meniscus Deficiency. An Analysis Of 156 Consecutive Cases at A Mean 10 Years of Follow-Up

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Risk Factors Affecting the Survival Rate of Collagen Meniscus Implant (CMI) For Partial Meniscus Deficiency. An Analysis Of 156 Consecutive Cases at A Mean 10 Years of Follow-Up

Gian Andrea Lucidi, MD, ITALY Alberto Grassi, PhD, ITALY Piero Agostinone, MD, QATAR Stefano Di Paolo, Eng, PhD, ITALY Giacomo Dal Fabbro, MD, AUSTRALIA Nicola Pizza, MD, ITALY Stefano Zaffagnini, MD, Prof., ITALY

Istituto Ortopedico Rizzoli, IRCCS, Bologna, ITALY

2023 Congress ePoster Presentation 2023 Congress Not yet rated

Anatomic Location

Knee

Anatomic Structure

Meniscus Medial Lateral

Diagnosis / Condition

Arthritis Tears

Treatment / Technique

Transplantation Implant

Sports Medicine

Outcome Studies

Summary: Outerbridge grade III-IV, lateral meniscus implants and greater time from the meniscectomy to implantation of the CMI implant were identified as risk factors for clinical and surgical failures.

Background

Collagen Meniscus Implant (CMI) is a biologic scaffold that could be used to replace meniscus host tissue after partial meniscectomy. The short-term results of this procedure have already been described, however, little is known about risk factors for failure.

Purpose

The goal of the present study was to determine the factors that predict failure of meniscus scaffold implantation in a large series of patients treated at a single institution, and to better define the indications for surgery.
Study Design: Case series

Methods

186 consecutive patients with a minimum 5-year follow-up who underwent CMI scaffold implantation or combined procedures were included in the analysis. Demographics and details of the surgery were obtained by chart review. Patients with a Lysholm score < 65 were considered a clinical failure. Surgical failure was defined as partial or total scaffold removal.

Results

156 patients (84%) with a mean age at surgery of 42.0 ± 11.1 were included in the final analysis at an average follow-up of 10.9 ± 4.3 years. The survival rate was 87.8%. Subgroup analysis identified Outerbridge grade III-IV (HR 3.8; P =.004) and a lateral meniscus implant (HR, 3.2; P= .0048) as risk factors for failure. The survival rate for the medial implants was 90.4% and 77.4% for the lateral implants. Finally, an Outerbridge grade III-IV (HR, 2.8; P =.000) and time from meniscectomy to scaffold greater than 10 years (HR, 2.8; P = .020) were predictive of surgical or clinical failure.

Conclusion

Collagen meniscus implant for partial meniscus deficiency provided good long-term results, with 87.8% of the implants still in-situ at a mean 10.9 years of follow-up. Outerbridge grade III-IV, lateral meniscus implants and greater time from the meniscectomy to implantation of the CMI implant were identified as risk factors for clinical and surgical failures.

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Risk Factors Affecting the Survival Rate of Collagen Meniscus Implant (CMI) For Partial Meniscus Deficiency. An Analysis Of 156 Consecutive Cases at A Mean 10 Years of Follow-Up

Risk Factors Affecting the Survival Rate of Collagen Meniscus Implant (CMI) For Partial Meniscus Deficiency. An Analysis Of 156 Consecutive Cases at A Mean 10 Years of Follow-Up

Background

Purpose

Methods

Results

Conclusion

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Risk Factors Affecting the Survival Rate of Collagen Meniscus Implant (CMI) For Partial Meniscus Deficiency. An Analysis Of 156 Consecutive Cases at A Mean 10 Years of Follow-Up

Risk Factors Affecting the Survival Rate of Collagen Meniscus Implant (CMI) For Partial Meniscus Deficiency. An Analysis Of 156 Consecutive Cases at A Mean 10 Years of Follow-Up

Background

Purpose

Methods

Results

Conclusion

More 2023 ISAKOS Congress Content