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Blood Flow Restriction-Enhanced Platelet-Rich Plasma: Preliminary Results of a Pilot Randomized Controlled Trial

Theodorakys Marín Fermín, MD
VENEZUELA

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Blood Flow Restriction-Enhanced Platelet-Rich Plasma: Preliminary Results of a Pilot Randomized Controlled Trial

Rafael Melo, MD, VENEZUELA Óscar Daniel Omaña Ávila, MD, VENEZUELA María Victoria Romero Rodríguez, MD, VENEZUELA María Isabel Mijares, Bioanalyst, VENEZUELA Cassandra Pacheco, Bioanalyst, VENEZUELA Fhabián Carrión-Nessi, MD, MSc, VENEZUELA Olivia Gonzalez Cordero , MD, VENEZUELA Theodorakys Marín Fermín, MD, VENEZUELA

Laboratorio Avilab, Caracas, Capital District, VENEZUELA

2025 Congress ePoster Presentation 2025 Congress Not yet rated

Treatment / Technique

Biologics

Sports Medicine

Basic Science Exercise Physiology

Summary: Bilateral low-load knee extensions under BFR may increase platelet concentration while decreasing IGF-1 levels in PRP.

Objective

To assess changes in platelet and leukocyte counts, insulin-like growth factor 1 (IGF-1), and interleukin 6 (IL-6) concentrations after low-load bilateral knee extensions under blood-flow restriction (BFR) in platelet-rich plasma (PRP).

Methods

A randomized controlled trial was conducted from June 2024 to date, including two groups: the intervention group, undergoing bilateral knee extensions under BFR, and the control group, performing bilateral knee extensions without BFR. Participants were randomly allocated in a 1:1 ratio. Healthy males aged 18-40 years with a Tegner activity scale (TAS) ≥ 5 and no musculoskeletal conditions interfering with exercise were enrolled. Exclusion criteria included systemic inflammatory diseases, cardiovascular risk factors, blood dyscrasia, TAS < 5, use of non-steroidal anti-inflammatory drugs or aspirin within one week before testing, or prior exercise on the testing day. Participants performed low-load bilateral knee extensions under BFR following a standard protocol of 30-15-15-15 repetitions with 30-second rest intervals at 80% limb occlusive pressure and 15 lbs load. PRP platelet and leukocyte counts, IGF-1, and IL-6 concentrations were measured before exercise and at 10, 20, and 30 minutes post-intervention. Participants' data were summarized using mean and standard deviation, and/or frequency and percentage. The Shapiro-Wilk test assessed the distribution of numerical variables. The repeated-measures analysis of variance (ANOVA) test was used for normally distributed variables, and the Friedman test was used for non-normally distributed variables. A p-value < 0.05 was considered statistically significant.

Results

At the time of submission, 11 out of the planned 22 participants were enrolled, with six in the intervention group and five in the control group. The mean age was 25 ± 5 years, body mass index was 24 ± 2.8 kg/m², and TAS was 6 ± 1 points. Platelet concentration in the intervention group peaked 10 minutes post-exercise and remained elevated for up to 30 minutes compared to the control group (p = 0.45). IGF-1 concentration in the intervention group was lower than in the control group throughout the testing period (p = 0.55). There were no significant differences between the intervention and control groups in PRP platelet and leukocyte counts, IGF-1, and IL-6 concentrations.

Conclusions

Low-load bilateral knee extensions under BFR may increase platelet concentration while decreasing IGF-1 levels in PRP. However, these preliminary results are not statistically significant.

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Blood Flow Restriction-Enhanced Platelet-Rich Plasma: Preliminary Results of a Pilot Randomized Controlled Trial

Blood Flow Restriction-Enhanced Platelet-Rich Plasma: Preliminary Results of a Pilot Randomized Controlled Trial

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Blood Flow Restriction-Enhanced Platelet-Rich Plasma: Preliminary Results of a Pilot Randomized Controlled Trial

Blood Flow Restriction-Enhanced Platelet-Rich Plasma: Preliminary Results of a Pilot Randomized Controlled Trial

Objective

Methods

Results

Conclusions