Summary: This study presents the comparison of clinical and radiographic outcomes of particulated juvenile articular cartilage in patients with shouldered versus unshouldered full-thickness cartilage defects of the patella.

Background

Particulated juvenile articular cartilage (PJAC) has demonstrated promising early results in the treatment of symptomatic articular defects of the patella. However, some uncertainty exists regarding the stability of this cell-based technique in lesions that are not well-contained or shouldered. The purpose of this study is to compare clinical and radiographic outcomes of PJAC in patients with shouldered versus unshouldered full-thickness cartilage defects of the patella.

Methods

A retrospective review of prospectively collected data from an institutional knee registry was conducted on patients treated with PJAC for a full-thickness symptomatic patellar cartilage lesion between March 2014 and August 2019. Cartilage defects were graded by the Outerbridge classification and characterized arthroscopically as shouldered or unshouldered. Patient reported outcome measures (PROMs) were obtained pre-operatively and post-operatively at 2-year follow-up. PROMs consisted of International Knee Documentation Committee (IKDC), Kujala, Knee Injury and Osteoarthritis Outcome Score (KOOS), KOOS Quality of Life (KOOS QOL), 12-Item Short Form Survey (SF-12), Veterans Rand 12 Item Health Survey (VR-12), Veterans Rand 6D (VR-6D), and the Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS). Post-operative MRI studies were read by a musculoskeletal fellowship-trained radiologist, characterizing the percentage of fill based on both coronal and sagittal images: 0%-33%, 34%-66%, or 67%-100%.

Results

A total of 64 patients underwent PJAC implantation with 32 (50%) shouldered and 32 (50%) unshouldered defects, respectively. The cohort was predominantly female (n = 47; 73.4%) with a mean age of 26.3 years (range, 14 – 44) and mean follow-up of 2.8 ± 1.6 years. Overall, all patients demonstrated statistically significant improvements in baseline KOOS QOL, HSS Pedi Fabs, IKDC, Kujala, SF-12 Physical Health, VR-12 Physical Health, VR6D (all P < .001). Radiographically, shouldered and unshouldered defects demonstrated similar rates of cartilage fill on postoperative MRIs (P = .604). Similarly, all PROMs were equivalent between shouldered and unshouldered defects at 2-year follow-up (P>0.05). However, higher improvements were seen in KOOS-PS (27.2 vs. 10.7; P = .015) and Kujala scores (44.3 vs. 26.9; P = .039) from baseline to 2-year follow-up in the shouldered group.

Conclusion

PJAC implantation led to significantly improved PROMs for both shouldered and unshouldered patellar cartilage lesions over time. Additionally, minimal differences were observed between shouldered and unshouldered defects treated with PJAC at 2-year follow-up.

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Grading Severity in Trochlear Dysplasia: a Pilot Study ePoster Presentation Juan Pablo Martinez-Cano, MD, MSc, PhD, COLOMBIA
The Flexion Angle and the Intra-Articular Version in Different MRI Recording Techniques Influence the Tibial Tuberosity - Trochlea Groove Distance ePoster Presentation Ole Grunenberg, MD, GERMANY Lucas K. Palma Kries, MD, GERMANY Michael J. Raschke, MD, Prof., GERMANY Christian Peez, MD, GERMANY Luise M. Hägerich, MD, GERMANY Elmar Herbst, MD, PhD, GERMANY Christoph Kittl, MD, MD(res), GERMANY Adrian Deichsel, MD, GERMANY
Quantitative Assessment of Knee Joint Kinematics In Patients with Recurrent Patellar Dislocation – Using a 3D-3D Surface Registration Technique and 4-D CT Analysis – ePoster Presentation Kazuya Kaneda, MD, PhD, JAPAN Kengo Harato, MD, PhD, JAPAN Satoshi Oki, MD, PhD, JAPAN Yutaro Morishige, MD, PhD, JAPAN Shu Kobayashi, MD, PhD, JAPAN Yasuo Niki, MD, PhD, JAPAN Tatsuaki Matsumoto, MD, PhD, JAPAN Ryo Sasaki, MD, PhD, JAPAN Masaya Nakamura, MD, PhD, JAPAN Takeo Nagura, MD, JAPAN
Anatomical Risk Factors For Patellofemoral Instability Differ Among Patients With Trochlear Dysplasia Depending On Their Dejour Classification ePoster Presentation Martin Hartmann, MD, SWITZERLAND Berfin Caliskan, SWITZERLAND Lazaros Vlachopoulos, MD, PhD, SWITZERLAND Jakob Ackermann, MD, SWITZERLAND Sandro Fucentese, Prof MD, SWITZERLAND
Medial PatelloTibial Ligament Reconstruction in Pediatric and Adolescent Patients with Patella Dislocation in Flexion ePoster Presentation Olivia C. Tracey, BA, UNITED STATES Joshua T. Bram, MD, UNITED STATES Emilie Lijesen, BS, UNITED STATES Akshitha Adhiyaman, BS, UNITED STATES Ruth H. Jones, BS, UNITED STATES Shae K Simpson, BS, UNITED STATES Ryann Davie, MD, UNITED STATES Yasir Alabdulkarim, MD, SAUDI ARABIA Daniel W. Green, MD, MS, UNITED STATES
Risk Factors For Patellofemoral Cartilage Lesions In Patients With Trochlear Dysplasia In The Setting Of Patellar Instability ePoster Presentation Jakob Ackermann, MD, SWITZERLAND Berfin Caliskan, SWITZERLAND Martin Hartmann, MD, SWITZERLAND Lazaros Vlachopoulos, MD, PhD, SWITZERLAND Sandro Fucentese, Prof MD, SWITZERLAND
3D Curvature Analysis as a Visualization Tool for Trochlea Dysplasia ePoster Presentation Johannes M. Sieberer, MSc, AUSTRIA Nancy Park, BS, UNITED STATES Shelby T Desroches, MS, UNITED STATES Curtis McDonald, MASc, UNITED STATES Kelsey Brennan, UNITED STATES Armita Razieh Manafzadeh, PhD, UNITED STATES Steven Tommasini, PhD, UNITED STATES Daniel Wiznia, MD John P. Fulkerson, MD, UNITED STATES
Straight Anteriorization Tibial Tubercle Osteotomy Is Safe and Effective for Patellofemoral Cartilage Lesions ePoster Presentation Nathan Varady, MD, MBA, UNITED STATES Arjun Khorana, BA, UNITED STATES Riley J. Williams, MD, UNITED STATES
Outcomes of Skeletally Immature Patients Undergoing Isolated Medial Patellofemoral Ligament Reconstruction: Data from the JUPITER Cohort ePoster Presentation Lauren H Redler, MD, UNITED STATES Elizabeth Rose Dennis, MD MS, UNITED STATES Bennett Propp, BS, UNITED STATES Heath Patrick Gould, MD, UNITED STATES Natalie K. Pahapill, BS, UNITED STATES Audrey Christine Wimberly, MPH, UNITED STATES Matthew William Veerkamp, BA, UNITED STATES Joseph T. Nguyen, MPH, UNITED STATES Eric J. Wall, MD, UNITED STATES Daniel W. Green, MD, MS, UNITED STATES Beth Ellen Shubin Stein, MD, UNITED STATES Shital N. Parikh, MD, UNITED STATES
Partial Lateral Patellar Facetectomy Is Beneficial For Patients With Patellofemoral Osteoarthritis: A Systematic Review and Meta-Analysis ePoster Presentation Kennan Yeo, MBBS, SINGAPORE Shawn Js Seah, MBBS, SINGAPORE Mark H.X. Yeo, MBBS, SINGAPORE Winston Lim, MBBS, MRCS, M.Med, SINGAPORE Denny T. T. Lie, MBBS, FRCS, FAMS, SINGAPORE
Clinical Outcomes For MPFL Reconstruction After First-Time Vs. Recurrent Patella Dislocations ePoster Presentation Serafina Faith Zotter, BS, UNITED STATES Georgia Butler, -, UNITED STATES Wei Shao Tung, BS, UNITED STATES Kristen N. Reikersdorfer, BA, UNITED STATES Connor Thomas Wright, BA, UNITED STATES Nikolaos K. Paschos, MD, PhD, UNITED STATES
Results Of Mpfl Reconstruction Using Soft Tissue Fixation Technique Associated With A Procedure On The Att For Patellar Instability : An Average Follow-Up Of 8.8 Years ePoster Presentation Marine Aubey, Student, FRANCE Aurore Emery, Resident, FRANCE Alexandre FERREIRA, PhD, FRANCE Rachel Le Dréau, MD, FRANCE Gregoire Duval, MD, FRANCE Gaëlle MAROTEAU, MD, FRANCE Christophe H. Hulet, MD, Prof., FRANCE
Outcomes of Isolated Medial Patellofemoral Ligament Reconstruction after First-Time and Recurrent Patellar Instability: Recurrence, Return to Sport, And Osteochondral Injury: Data from the JUPITER Cohort ePoster Presentation Jacqueline M. Brady, MD, UNITED STATES Bennett Propp, BS, UNITED STATES Erick Marigi, MD, UNITED STATES Elizabeth Rose Dennis, MD MS, UNITED STATES Natalie K. Pahapill, BS, UNITED STATES Haley D. Smith, BS, UNITED STATES Audrey Christine Wimberly, MPH, UNITED STATES Joseph T. Nguyen, MPH, UNITED STATES Eric J. Wall, MD, UNITED STATES Daniel W. Green, MD, MS, UNITED STATES Beth Ellen Shubin Stein, MD, UNITED STATES Shital N. Parikh, MD, UNITED STATES
Significantly Greater Incidence Of Patella Fracture After Medial Patellofemoral Ligament Reconstruction For Patients Age 20 And Under ePoster Presentation Brendan Fitzgerald, BS, UNITED STATES Cale A. Jacobs, PhD, UNITED STATES Christian Lattermann, MD, UNITED STATES Miho J. Tanaka, MD, PhD, UNITED STATES

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Comparative Clinical and Radiographic Outcomes of Particulated Juvenile Articular Cartilage Implantation in Shouldered and Unshouldered Patella Cartilage Lesions

Comparative Clinical and Radiographic Outcomes of Particulated Juvenile Articular Cartilage Implantation in Shouldered and Unshouldered Patella Cartilage Lesions

Background

Methods

Results

Conclusion

Knee Patellofemoral ePosters

Sign-in to ISAKOS

Comparative Clinical and Radiographic Outcomes of Particulated Juvenile Articular Cartilage Implantation in Shouldered and Unshouldered Patella Cartilage Lesions

Comparative Clinical and Radiographic Outcomes of Particulated Juvenile Articular Cartilage Implantation in Shouldered and Unshouldered Patella Cartilage Lesions

Background

Methods

Results

Conclusion