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Genetic Evidence Suggests Education Reduces Risk Of Patellar Dislocation: Insights From Mendelian Randomization

Chao Zhang
CHINA

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Genetic Evidence Suggests Education Reduces Risk Of Patellar Dislocation: Insights From Mendelian Randomization

Chao Zhang, CHINA Qian Wu, CHINA

Baoji Hospital of Chinese Traditional Medicine, Baoji, Shaanxi, CHINA

2025 Congress ePoster Presentation 2025 Congress Not yet rated

Anatomic Location

Knee Patellofemoral

Diagnosis / Condition

Dislocation

Patellofemoral

Recurrent Subluxation and Dislocation

Summary: In our study, we identified evidence indicative of a causal relationship between low levels of EA and the incidence of recurrent patellar dislocation.

Purpose

Musculoskeletal disorders are associated to some extent with educational attainment (EA). Nevertheless, these studies are not fully conclusive. The purpose of this study was to examine the genetic causality between educational attainment and recurrent patellar dislocation using Mendelian randomization(MR).

Method

By analyzing UK Biobank and IEU databases for genome-wide association studies (GWAS), 8 exposures to education attainment (EA) were identified, totaling 1067 single nucleotide polymorphisms (SNPs). The FinnGen consortium provided genetic data on recurrent patellar dislocations.Using the TwoSampleMR package in R, we performed a two-sample Mendelian randomization analysis to determine whether the risk for recurrent patellar dislocation is affected by EA.
Result: According to inverse variance weighting (IVW), EA has a variable effect on recurrent patellar dislocation according to genetic prediction, and RPD is negatively associated with the following educational attainments: educational attainment (years of education) (ebi-a-GCST90029013)（OR 0.91 with a 95% confidence interval (Cl) of 0.85-0.98, p=0.02), Years of schooling (ieu-a-1239) (OR 0.56, 95% Cl 0.39-0.78, p < 0.001), College or University degree (ukb-a-397) (OR 0.36 95% Cl 0.18-0.75, p = 0.006), A levels/AS levels or equivalent (ukb-a-399) (OR 0.16, 95% Cl 0.05-0.56, p = 0. 003), Other professional qualifications eg: nursing teaching ( ukb-a-403) (OR 0.02, 95% Cl 0.0004-0.66, p = 0.029), College or University degree (ukb-b-16489) (OR 0.33, 95% Cl 0.16-0.68, p = 0.0026) and O levels/GCSEs or equivalent (ukb-b-18099) (OR 0.07, 95% Cl 0.007-0.68, p = 0.02). However, Qualifications:None of the above(ukb-a-398) was positively associated with recurrent patellar dislocation (OR 5.47, 95% CI 1.37-21.82, p = 0.03), nor were any levels of multidimensionality or heterogeneity found.

Conclusions

Recurrent patellar dislocation is somewhat influenced by educational attainment, but not significantly. On the other hand, lack of educational attainment significantly increases the possibility of recurrent patellar dislocation. In our study, we identified evidence indicative of a causal relationship between low levels of EA and the incidence of recurrent patellar dislocation. Future research should prioritize the identification of risk factors, including lifestyle and dietary habits, associated with EA to elucidate potential causal relationships and inform the development of evidence-based interventions for affected individuals.

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CLINICAL AD RADIOLOGICAL OUTCOMES AFTER ISOLATED MEDIAL PATELLOFEMORAL RECONSTRUCTION FOR RECURRENT PATELLAR DISLOCATION WITH COMPLETELY IMPLANT FREE TECHNIQUE AMONG POPULATION OF YOUNG SPORT PATIENTS ePoster Presentation Matteo Baldassarri, MD, ITALY Luca Perazzo, MD, ITALY Diego Ghinelli, ITALY Sarino Ricciardello, MD, ITALY Alessandro Parma, MD, ITALY Roberto Buda, Prof., ITALY
Comparative Clinical and Radiographic Outcomes of Particulated Juvenile Articular Cartilage Implantation in Shouldered and Unshouldered Patella Cartilage Lesions ePoster Presentation Ryann Davie, MD, UNITED STATES Brittany Margaret Ammerman, MD, MBS, UNITED STATES Bennett Propp, BS, UNITED STATES Erick Marigi, MD, UNITED STATES William A. Marmor, MD, UNITED STATES Kiera A. Kingston, MD, UNITED STATES Natalie K. Pahapill, BS, UNITED STATES Alissa J. Burge, MD, UNITED STATES Audrey Christine Wimberly, MPH, UNITED STATES Joseph T. Nguyen, MPH, UNITED STATES Elizabeth Rose Dennis, MD MS, UNITED STATES Beth Ellen Shubin Stein, MD, UNITED STATES
Outcomes Of Arthroscopic Patella Realignment In Children And Adolescents With A Minimum 2-Year Follow Up ePoster Presentation Serafina Faith Zotter, BS, UNITED STATES Georgia Butler, -, UNITED STATES Wei Shao Tung, BS, UNITED STATES Connor Thomas Wright, BA, UNITED STATES Kristen N. Reikersdorfer, BA, UNITED STATES Nikolaos K. Paschos, MD, PhD, UNITED STATES
Influence of tibial tuberosity movement direction on postoperative outcomes of combined Maquet procedure and autologous cartilage implantation for patellofemoral cartilage injury ePoster Presentation Junya Tsukisaka , MD, JAPAN Atsuo Nakamae, MD, PhD, JAPAN Akinori Nekomoto, MD, PhD, JAPAN Naofumi Hashiguchi, MD,MPH, JAPAN Shunya Tsuji, MD, JAPAN Nobuo Adachi, MD, PhD, JAPAN
Radiologic Risk Factors for Osteochondral Fractures in First-Time and Recurrent Patellar Instability Patients ePoster Presentation James McGinley, BS, UNITED STATES Henry B. Ellis, MD, UNITED STATES Bennett Propp, BS, UNITED STATES Matthew William Veerkamp, BA, UNITED STATES Philip Wilson, MD, UNITED STATES Dennis Kramer, MD Shital N. Parikh, MD, UNITED STATES Beth Ellen Shubin Stein, MD, UNITED STATES
Return to Sports is Faster with Combined Reconstruction of the MPFL and MQTFL Compared to Isolated MPFL Reconstruction: Preliminary Results ePoster Presentation Luís Duarte Silva, MD, PORTUGAL Cristina Valente, PhD, PORTUGAL Eluana Gomes, PhD, PORTUGAL Cátia Cardoso, Bsc, PORTUGAL Alberto Monteiro, MD, PORTUGAL Nuno Pais, MD, MSc, PhD student, PORTUGAL Bruno S. Pereira, MD, PhD, Prof., PORTUGAL Tiago Barbosa Da Frada, MD, PORTUGAL Renato Andrade, PhD student, PORTUGAL João Espregueira-Mendes, MD, PhD, Full Prof., PORTUGAL

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Genetic Evidence Suggests Education Reduces Risk Of Patellar Dislocation: Insights From Mendelian Randomization

Genetic Evidence Suggests Education Reduces Risk Of Patellar Dislocation: Insights From Mendelian Randomization

Purpose

Method

Conclusions

Knee Patellofemoral ePosters

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Genetic Evidence Suggests Education Reduces Risk Of Patellar Dislocation: Insights From Mendelian Randomization

Genetic Evidence Suggests Education Reduces Risk Of Patellar Dislocation: Insights From Mendelian Randomization

Purpose

Method

Conclusions