Introduction

The 2-octyl cyanoacrylate topical adhesive with flexible self-adhesive polyester mesh (Dermabond Prineo) is becoming widely used in many surgical fields. The purpose of this study was to compare the efficacy and safety between Dermabond Prineo and subcuticular suture for skin closure in patients undergoing same-day bilateral total knee arthroplasties(TKAs).

Materials And Methods

A prospective, double-blind randomized controlled trial was performed in 51 patients scheduled to undergo same-day bilateral TKAs. One knee was randomly assigned to the Dermabond Prineo and the other knee was allocated to the subcuticular suture. As primary outcomes, Vancouver Scar Scale (VSS) was evaluated at 6 months and Patient and Observer Scar Assessment Scale (POSAS) was evaluated at 2 weeks, 6 weeks, 3 months, and 6 months. Secondary outcomes included cosmesis efficacy (Hollander Wound Evaluation Scale [HWES], and cosmesis visual analogue scale [VAS]), time and pain efficiency (skin suture time, stitch out time, and stitch out pain VAS), and safety (wound complications).

Results

There were no significant differences in VSS and POSAS at 6 months. Although there were no significant differences in HWES at 2 weeks, the Dermabond Prineo group showed better Step-off border item of HWES . There was also no difference in cosmesis VAS at 6 months. The Dermabond Prineo group showed superior results in time efficiency with similar pain scale and wound complications to the subcuticular suture group.

Conclusion

Dermabond Prineo provided quicker wound closure, stitch out time, and better wound margin coaptation in the early postoperative period, but similar wound efficacy compared to subcuticular suture.