Summary: Prospective, randomized clinical study in 50 patients who underwent an anatomic tunnel ACL-R technique with autologous hamstring graft. In this clinical series, PRP in ACL-R did not improve clinical or functional outcomes at 12 years of follow-up.

Purpose

This study aimed to compare the long-term effect of autologous platelet-rich-plasma concentrate (PRP) in anterior cruciate ligament reconstruction (ACL-R). The hypothesize was that PRP did not affect clinical and functional outcomes.

Methods

Prospective, randomized clinical study in 50 patients who underwent an anatomic tunnel ACL-R technique with autologous hamstring graft. Patients were randomly assigned into two study groups: Intervention Group (30 patients with PRP enhancement during the procedure) and Control Group (20 patients). Multiligamentary knee injuries and revision surgeries were excluded. At a minimum follow-up of 10 years, groups were compared for knee reintervention of any cause, range of motion (ROM), and functional outcomes (Lysholm, Tegner, and IKDC). Statistical analysis included Student's t and U Mann-Whitney tests. Significance was set at p<0.05.
PRP was obtained from a venous blood sample of each patient during the ACL-R procedure. Following the reconstruction and intra-articular fluid removal, 10 ml of PRP were applied into both bone tunnels (3ml each) and the intra-articular graft portion (4ml).

Results

Groups [Intervention/Control] did not differ regarding mean age [29 years (14-52)/25 years (15-53); p=0.14], male sex [68%/81%; p=0.17. Mean follow-up: 12 (11-13) years [Intervention group 12 years (11-12)/Control group 12 years (11-14)].
No statistical difference were found between groups for surgical reinterventions (p=0.37), ROM (0.25) and functional outcomes (Lysholm p=0.68; IKDC p=0.55; and Tegner p=0.90)

Conclusions

In this clinical series, PRP in ACL-R did not improve clinical or functional outcomes at 12 years of follow-up.

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PRP in ACL Reconstruction Does Not Improve Clinical and Functional Outcomes: Results from a Prospective Randomized Clinical Study at 12 Years Follow-Up

PRP in ACL Reconstruction Does Not Improve Clinical and Functional Outcomes: Results from a Prospective Randomized Clinical Study at 12 Years Follow-Up

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PRP in ACL Reconstruction Does Not Improve Clinical and Functional Outcomes: Results from a Prospective Randomized Clinical Study at 12 Years Follow-Up

PRP in ACL Reconstruction Does Not Improve Clinical and Functional Outcomes: Results from a Prospective Randomized Clinical Study at 12 Years Follow-Up

Purpose

Methods

Results

Conclusions